Toxicity and Environmental Risk of Oxytetracycline and Effect in Leukocytes of Mato Grosso (Hyphessobrycon eques)
DOI:
https://doi.org/10.5132/jbse.2012.02.002Keywords:
Fish, Antibiotic, Lethal concentration, HematologyAbstract
The oxytetracycline (OTC) is one of antibiotic more used to control bacterial diseases on fishes. The objectives were to evaluate the toxicity of OTC and the environmental risk and its effects in leukocytes of Mato grosso (Hyphessobrycon eques). The fishes used in the experiment had average weight 0.22 ± 0.2 g and they were acclimated for ten days in bioassay room and were exposed at 2.0; 4.0; 6.0 and 8.0 mg L-1 of OTC and one treatment control. The tests were carried out in a completely randomized design, with four replicates and in the end, samples of blood were collected for leukocytes counting. For the classification of the environmental risk was utilized the LC50 and the estimated environmental concentration (CAE) of the antibiotic. The lethal concentration 50% (LC(I)50;96h) estimated of the OTC was 5.49 mg L-1 withlower limit 5.08 mg L-1 and upper limit 5.95 mg L-1. The OTC cause moderately intoxication environmental risk with the small CAE and high intoxication environmental risk with the higher CAE. There were not differences (p>0.01) in percentages of eosinophils, granulocytic cells and basophils but occurred lymphopenia and monocytosisin 4.0 mg L-1. The OTC is moderately toxic and cause intoxication environmental risk for Mato grosso fish and caused stress in 4.0 and immune suppressor at 6.0 mg L-1.
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